(OCD) Research














The OCD research program is dedicated to the mission of improving the lives of people with obsessive-compulsive disorder (OCD) and related disorders by conducting cutting edge research to transform how we understand and treat these disorders. For the patients of today, we examine how to combine and sequence current treatments to maximize outcome, and we explore novel treatments. For the patients of tomorrow, we collaborate with experts in neuroimaging, genetics, and basic science to examine what causes obsessions and compulsions. Below is a list of our current research opportunities.


Research Studies

Brain signatures of OCD: In collaboration with OCD experts across five countries, we are using imaging methods to examine multiple brain circuits thought to underlie OCD behavior. Identifying brain signatures of OCD will provide robust new treatment targets and help pave the way to precision psychiatry where individual brain signatures can help guide treatment choices.

Precision Medicine for OCD: In a collaboration with the Institute of Genomic Medicine, the Center for OCD and Related Disorders is looking at the genes of individuals with OCD to see if we can identify genes that may have put those individuals at risk for OCD. This study seeks to identify genes that may explain why an individual developed OCD and to identify which treatments might work best for them.

Novel therapeutics: We have partnered with Biohaven Pharmaceuticals to investigate the efficacy of a novel medication that affects the brain’s glutamate system. We are seeking individuals with OCD who are taking an SRI, and still experiencing clinically significant symptoms.

State-of-the-art technology: In collaboration with nOCD, we are investigating the feasibility of a mobile application for cognitive behavioral therapy. With therapist guidance, individuals with OCD can access support and therapeutic techniques on the go from their phone.

For more information on all of our current studies, visit us at



Publications on the Quality of Care in OCD

Treatment of Obsessive Compulsive Disorder in a Nationwide Survey of Office Based Practice: 

This study examined what treatments adults with OCD receive during treatment visits to U.S. office based physicians. Among the 316 visits examined, most were treated with psychotropic medications (84%), most commonly Serotonin Reuptake Inhibitors (69%) and less commonly psychotherapy (39%).

Patient Preferences and Acceptability of Novel Treatment for Obsessive Compulsive Disorder: 

This study examine preferences for and acceptability of treatments for OCD. Among 216 adults with moderate OCD symptoms, preferences for exposure and response prevention and medications were similar (55% and 45% respectively). Participants preferred the addition of exposure and response prevention over additional medications if they were still experiencing symptoms on medication for OCD.

Acceptability, Feasibility, and Effectiveness of Internet-Based Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in New York: 

This study examined if an Internet Based Treatment (based on exposure and response prevention) program for OCD is acceptable, feasible and effective. In 40 adults with moderate to severe OCD, we found that the treatment program was effective in reducing OCD symptoms and symptoms of depression and improving quality of life. Participants found the program acceptable and it was feasible to implement.


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